Vitamin B6 (Pyridoxine) Expand The diagnosis of pyridoxine dependency should be suspected in every infant with convulsions in the first eighteen months of life. Certain clinical features may be indicative, including: Seizures of unknown origin in a previously normal infant without an abnormal gestational or perinatal history. A history of severe convulsive disorders, in both the family and the individual. The occurrence of long-lasting focal or unilateral seizures, often with partial preservation of consciousness. Irritability, restlessness, crying and vomiting preceding the actual seizure.* If large amounts of B6 alone are given, the need for other B vitamins, particularly vitamin B2 and pantothenic acid, is so increased that harm can be done unless they too are supplied. *Morello, Gaetano. (1996) "Treating Epilepsy Effectively," American Journal of Natural Medicine (October), 14-20.